Cam Fowler's 15-season career with the Anaheim Ducks ended when he was traded to the St. Louis Blues on Dec. 14, 2024, for defenseman prospect Jeremie Biakabutuka and a second-round pick in the 2027 NHL Draft, a move Ducks general manager Pat Verbeek said was difficult " considering what Cam has meant to this organization. He has been a valuable and respected member of our team for 15 seasons, representing the Ducks with ultimate class."

Fowler, who was the longest-tenured player in Ducks history and second in games played (991) behind Ryan Getzlaf (1,157), had one shot on goal and played 17:57 in his St. Louis debut, a 2-1 overtime loss to the Dallas Stars at American Airlines Center the night of the trade. Nine games into his tenure with the Blues, Fowler made history by becoming the first player to play his 1,000th game outdoors. He scored two goals in a 6-2 victory against the Chicago Blackhawks in the Discover NHL Winter Classic at Wrigley Field on Dec. 31.

Fowler signed a three-year contract with the Blues on Sept. 27 that was to begin with the 2026-27 season.

Born in Windsor, Ontario-born, and raised in Farmington Hills, Michigan, Fowler chose to wear No. 4, the same as Bobby Orr, in tribute to his father's favorite player. He was a first-round pick (No. 12) by the Ducks in the 2010 NHL Draft and was the second-youngest player in Ducks history to make his NHL debut (18 years, 307 days) Oct. 8, 2010. Playing close to home against the Detroit Red Wings at Joe Louis Arena, Fowler blocked five shots in that game. One night later against the Nashville Predators, Fowler had an assist for his first NHL point.

On Oct. 17, 2010, Fowler's first NHL goal opened the scoring in a 3-2 win against the Phoenix Coyotes. During that game, a hit from Shane Doan broke Fowler's nose, keeping him out for six games.

Fowler returned in early November and scored a power-play goal in three straight games, making him the second rookie defenseman and the youngest defenseman in NHL history to do so. Fowler also became the second rookie defenseman in League history to score two overtime goals in one season.

Fowler finished 2010-11 as the only defenseman in his draft class to play that whole season in the NHL. He was second among rookie defensemen in goals (10) and points (40) in 76 games. Fowler was third among rookies in average time on ice (22:07) and set Ducks records for goals and points by a first-year defenseman and an Anaheim mark for rookie assists.

In the 2011 Stanley Cup Playoffs, Fowler played in all six games of Anaheim's first-round series against Nashville and he led Ducks defensemen with four points in the postseason. On Nov. 13, 2011, at 19 years and 343 days, Fowler scored two goals against the Minnesota Wild to become the youngest Ducks player ever with a two-goal game.

After the season, the Ducks signed Fowler to a five-year contract Sept. 15, 2012. He signed an eight-year contract July 1, 2017.

Fowler had his first NHL hat trick in a 3-2 overtime win against the Columbus Blue Jackets on Nov. 4, 2018. Eight days later, he was hit in the face by a shot from Nashville Predators forward Craig Smith. He needed surgery for a facial fracture and missed 23 games.

Fowler played two seasons with the USA Hockey National Team Development Program. He helped the United States finish first at the 2010 World Junior Championship and the 2009 Under-18 World Championship. He also played for the U.S. at the 2014 Sochi Olympics.

Fowler was the highest scoring defenseman in the 2010 Memorial Cup and helped Windsor follow up its Ontario Hockey League championship by winning the tournament.